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Within the mitochondria, polyprenyl diphosphate synthase complex, composed of PDSS1 and PDSS2, catalyzes the sequential head-to-tail polymerization of these units to form a polyprenyl diphosphate chain of species-specific length

We also think it is being discussed in ways that do patients more harm than good

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With reduced preload the heart does not have to exert as much contractile force which reduces the oxygen requirements of the heart and also reduces ventricular transmural pressure resulting in reduced compression of the coronary arteries allowing for more efficient blood flow through the heart