Abstract Background Glucagon-like peptide-1 receptor agonists, originally developed for managing type 2 diabetes, have gained attention for their weight-reducing and broader biological effects
While RWE is inevitably limited by the possibility of residual confounding [16], we welcome the careful attention paid by the authors of EMPRISE to minimise possible sources of bias [16], such as the steps taken to address concerns relating to immortal time bias that have been raised with previous RWE studies [19,20,21], providing more confidence in its results
The most balanced user reports consistently emphasize that the fundamentals, diet, exercise, protein intake, sleep, hydration, drove the majority of their results, and that the levocarnitine addition felt like a minor enhancement at best
Although the market for diabetes drugs is fiercely competitive, Jardiance gained a substantial advantage when it became the first to show reduced risk of cardiovascular events in high-risk type 2 diabetes patients in the EMPA-REG OUTCOME trial in late 2015