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At carnitine-replete levels, the mitochondria can process fatty acids at their maximum rate for that individual's metabolic capacity, producing more aerobic ATP from fat oxidation and reducing the reliance on muscle glycogen as an alternative energy substrate
Reasonable candidates are patients already engaged in a supervised weight-loss programme with diet and activity in place, who understand it is adjunctive
Samms RJ, Christe ME, Collins KA et al (2021) GIPR agonism mediates weight-independent insulin sensitization by tirzepatide in obese mice
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