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dysfunction of these organelles impairs autophagic flux and promotes pancreatitis development

Only 2.3% of clinical trial participants discontinued treatment specifically due to diarrhea, meaning 97.7% found the side effect manageable enough to continue their weight loss journey

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Among all the active GLP-1R structures, H363 6.52b dipped into the TMD core whereas it is reoriented ~90 to an outside-facing position and formed a hydrogen bond with Q394 7.49b through dismissal of the hydrogen bond with the backbone carbonyl oxygen atom of P358 6.47b