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Correlative light electron microscopy (CLEM) Mixed cortical cultures from prpTDP-43 A315T mice were plated on a gridded glass coverslip bottom petridishes (MetTek) and cultured for 3 DIV either in SFM alone or treated with 1 M NMN (Sigma)

Rather than just feeling less hungry, many reported a genuine disinterest in food, as if the psychological drive to eat had been turned down alongside the physical hunger signals