Dosing is individualized, but a typical protocol titrates from a starting dose up to a target dose over 2 to 4 weeks, injected 5 days on and 2 days off, in defined cycles with scheduled breaks between them
Menopause plays a substantial role in aging of the skin
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Melatonin taken exogenously in the afternoon or early evening can advance the circadian phase, shifting the rhythm earlier, which is why it is used to treat circadian phase disorders like jet lag or advanced sleep phase in elderly