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14 The extent to which each or any of these reactions accounts for enhanced platelet activation in vivo is difficult to ascertain owing to limitations of measuring intermediates, the complexity and multiplicity of the reactions that occur in the intracellular environment, 15 and the uncertainty of the microenvironmental concentrations of coreactants in the extracellular space in the immediate vicinity of an aggregated platelet

Samblas, M., Milagro, F