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reported that the exosomes present in the CSF of PD patients exhibit -syn aggregate formation
Retention of this unmodified histidine in retatrutide preserves potent glucagon receptor agonism, which is a defining structural distinction compared to tirzepatide, where this position is also histidine but the molecule lacks meaningful glucagon receptor activity due to other sequence differences
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Tirzepatide is a dual GIP/GLP-1 receptor agonist, meaning it activates two different metabolic pathways simultaneously
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