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The microbiotagutbrain axis in mental and neurodegenerative disorders: opportunities for prevention and intervention

Binding to the -subunits activates the tyrosine kinase activity in the -subunits, initiating autophosphorylation of the receptor in both neuronal and glial cells

There are ongoing studies including a large phase 3 trial underway to determine if semaglutide will meet any of these clinical endpoints for FDA approval

The SURMOUNT-4 trial showed even steeper rebounds with tirzepatide, with participants regaining more than 50% of their weight loss over 52 weeks after stopping