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This is attributed to its ability to stimulate the production of growth factors, promote angiogenesis (the formation of new blood vessels), and elevate the levels of other proteins that support tissue regeneration

However, researchers working with very small doses may prefer more dilute solutions, while those needing larger doses might opt for higher concentrations to minimise injection volumes

However, the magnitude of VEGF change and the upstream signaling pathway driving it are not established with the precision needed to predict dose-response in humans

This timing allows AMPK activation to proceed without NAD+ limitation, maximising mitochondrial biogenesis and fat oxidation