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Fe 3+ subsequently binds to transferrin (TF) or lactoferrin (LF) to form a TFFe 3+ complex, which is then recognized and internalized by transferrin receptor 1 (TFR1) on the cell surface (Zhao et al., 2025b)
A key characteristic of the BBB compared to peripheral vasculature is the arrangement of endothelial cells, which include tightly sealed cell-to-cell contacts called tight junctions (Moyaert et al., 2023)
Loss of claudins 2 and 15 from mice causes defects in paracellular Na + flow and nutrient transport in gut and leads to death from malnutrition
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