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For example, in patients requiring insulin, SARS-CoV infection was associated with a rapidly increasing need for high doses of insulin (often approaching or exceeding 100 IU per day) 26

Following the remodelling phase, a higher proportion of synthesised type I collagen, a corresponding decrease in cellularity, glycosaminoglycan content and type III collagen (Sharma and Maffulli 2005) can be observed