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92 Carnitine deficiency, resulting from the downregulation of OCTN1 and OCTN2, may reduce the transfer of long-chain fatty acids from the cytoplasm to the mitochondria, limiting their oxidation
Semaglutide is a GLP-1 medication that mimics the action of the naturally occurring glucagon-like peptide-1 hormone to suppress appetite, increase insulin secretion, decrease hunger cravings, and reduce calorie intake
An observational cohort study involving 168 pregnant women exposed to GLP-1 receptor agonists during the first trimester found a 2.6% prevalence of major birth defects, comparable to 2.3% in the diabetic reference group
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