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DISCUSSION Patient adherence to antihyperglycemic treatment, medications is surprisingly low, described for GLP-1 RA to fall between 29% and 54%, resulting in suboptimal T2D management carrying increased risk of stroke, heart and kidney disease, amputations and blindness ( 60 )
For people already managing GI side effects with careful dietary adjustments , early dosing can undo weeks of careful management
Tirzepatide added GIP receptor activation to GLP-1, demonstrating that multi-receptor approaches could enhance weight loss without proportionally increasing side effects
Huang C, Dong L, Zhao B, Lu Y, Huang S, Yuan Z
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