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In contrast, the ECL1 of GIPR displays notable flexibility, accommodating a variety of conformations to recognize peptides and allowing for sequence variability

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Discussion The results of this population based cohort study, designed to emulate a randomised controlled trial, suggest that the combined use of GLP-1 receptor agonists and SGLT-2 inhibitors is associated with a reduced risk of major adverse cardiovascular events and serious renal events, compared with using either drug class alone

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