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GHB withdrawal symptoms: Symptoms may begin as soon as a few hours after the last dose and typically include: Anxiety, agitation, and increased heart rate Insomnia, tremor, and profuse sweating Nausea and vomiting Confusion, hallucinations, and paranoid thoughts in severe cases Seizures and autonomic instability in severe withdrawal GHB withdrawal timeline: Acute withdrawal commonly lasts several days to a week, though severe or complicated withdrawal may require longer medical monitoring and can persist in a protracted form for weeks in some individuals

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Preclinical studies show that both short acting agonists (i.e