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doi: 10.1016/S0021-9258(19)38942-2 46 WeinstockPHBisgaierCLAalto-SetlKRadnerHRamakrishnanRLevak-FrankSet al

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Novo Nordisks semaglutide aces another outcomes trial Novo Nordisk has halted a phase 3 trial of its Ozempic formulation of GLP-1 agonist semaglutide in patients with type 2 diabetes and chronic kidney disease (CKD) early after signs of a clear benefit with the drug

The 'central planning' mechanism of GLP-1: from molecular signaling to systemic regulation GLP-1 is an incretin secreted by intestinal L cells, and its bioactive forms (GLP-1 (7-37) and GLP-1 (7-36) amide) have a half-life of only 2.1-2.4 minutes