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A randomized controlled trial on the effect of metformin in CHD patients without diabetes showed that it (2000 mg/day, P.O for 12 months) not only decreased oxidative stress but also lowered left ventricular mass (LVM) and improved blood pressure [227]
doi:10.3389/fnut.2022.853058
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Importantly, this suppression is also glucose-dependentglucagon responses to hypoglycemia remain intact, preserving a critical protective mechanism
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