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Its use is being explored for various health applications, including anti-aging, muscle wasting disorders, and increasing the bodys resting metabolic rate, though its long-term effects and safety are still subjects of ongoing research
sales of ~$4.3B, and recently approved Zepbound (~$1.7B 1H24)
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Additionally, SGLT2i can lower HbA1c levels by 0.5-1.0% and support weight loss ( Studies have indicated that increased expression of the sodium-hydrogen exchanger isoform 1 (NHE-1) is linked to heart failure and may contribute to the development of hypertrophy and cardiac injury during ischemia and reperfusion ( Of note, long-term use of SGLT2i may lead to a reduction in glycosuric efficacy, without a corresponding decline in cardiovascular benefits
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