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HO-1 is involved in a variety of pathological mechanisms of diabetic complications, especially inflammation and cell death caused by oxidative stress
Treatment with KBP-089 and liraglutide dose-dependently lowered body weight 15% (at 2.5 g/kg/day) and 7% (at 400 g/kg/day) in HFD rats, respectively, while the combination resulted in a 21% body weight reduction, which was mirrored by reduction in fat depot sizes
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