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Then, a 10 min recording with excitation was started, and after establishment of a baseline consisting of 10 frame pairs, NMDA (50 M, Tocris) + GLP-1 or GLP-1MK-801 was bath-applied
Tirzepatide was found to be effective in promoting insulin secretion dependent on glucose through GIPR and GLP1R activation in both in vivo and in vitro models
Although it requires daily injection, its cardiovascular profile and lower cost make it a contender for long-term management
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