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3 GLP-1R localization and mechanistic pathways in metabolic and behavioral regulation GLP-1 Rs exhibit high expression in pancreatic -cells in both rodents and humans, where they play a pivotal role in mediating glucose-dependent insulin secretion (Nauck et al., 1993
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Braz J Med Biol Res 45:546556 Schmidt-Sommerfeld E, Penn D, Kerner J, Bieber LL, Rossi TM, Lebenthal E (1989) Quantitation of urinary carnitine esters in a patient with medium-chain acyl-coenzyme A dehydrogenase deficiency: effect of metabolic state and l-carnitine therapy
Collectively, all these outcomes of research studies and clinical trials advocated that the surface modifications of nanoparticles by using antibodies or affibodies through protein engineering could pave the way for nanoformulations to escape from the phagocytic system, resulting in minimized adsorption of serum proteins due to the protein corona effect [216]
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