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Reducing oxidative stress is crucial because it influences the activity of tyrosinase

Transcriptional up-regulation of the mouse cytosolic glutathione peroxidase gene in erythroid cells is due to a tissue-specific 3 enhancer containing functionally important CACC/GT motifs and binding sites for GATA and Ets transcription factors

HIGH GT EXPRESSION AND INTRATUMOR DRUG ACTIVATION The high expression of GT within aggressive and drug-resistant tumors implies that GSH-conjugated prodrugs, activated at the cell surface by GT, should be particularly effective against GT-positive tumors

Published Phase 2 studies lasted 12 or 24 weeks