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( The preserved insulinotropic effect of GLP-1 in patients with T2DM may seem incompatible with the almost complete loss of incretin effect in these patients ( In the late 80ties, researchers began looking for the new glucagon-like peptides in the brain, inspired by the reports of immunoreactive glucagon in certain neurons of the brain ( The demonstration of the GLP-1 receptor and its expression on the beta cells was of course consistent with its powerful insulinotropic effects ( Nevertheless, treatment of diabetes was obviously of great interest, but how to do it
GLP-1 medications like Ozempic and Wegovy are meant for long-term use
