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We felt it was important to document her clinical course to inform clinicians facing similarly complex patients. Indeed, children with early-onset obesity develop insulin resistance, liver dysfunction, and beta cell decline much more rapidly than adults because their organs and metabolic systems are developing, which makes them more vulnerable to the harmful effects of excess adiposity
Compared with the initiation of sulfonylurea, the addition of SGLT2is to GLP-1RA therapy was associated with a significantly lower incidence rate of the composite cardiovascular endpoint (9.9 versus 13.0 per 1,000 person-years
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10.1016/j.bbrc.2020.08.045 3 AltherrE.RainwaterA.KavianiD.TangQ.GulerA
