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In a 2-year trial involving patients with type 2 diabetes mellitus (T2DM) and high cardiovascular risk, more events of diabetic retinopathy complications occurred in the patients treated with semaglutide injection (3%) compared to placebo (1.8%)

The p21-derived tumor suppressor peptide from the C-terminal region can inactivate PCNA, which is necessary for cell proliferation [53]

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Lyophilized powder is more temperature-stable but still benefits from controlled storage