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Communication was also severely affected, with MIA male mice producing significantly fewer USVs during male-female interactions, emitting only 101 36 USVs compared to 523 117 in control mice

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However, an uncontrolled increase in their concentrations leads to a chain of unwanted radical reactions that target the main biomolecules (DNA, RNA, lipids, and proteins) and alters key processes such as nucleic acid oxidation, lipid peroxidation, thereby contributing to the loss of cellular architecture, to impaired cell signalling and, ultimately, to cell death [25, 46]

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