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People with pre-existing arrhythmias, heart failure, or ischaemic heart disease may face heightened cardiac risk due to retatrutide's heart rate-elevating effects and glucagon receptor activity

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per VivioMD's disclosures, these medical groups determine eligibility based on medical history, and the prescribing decision rests entirely with the evaluating clinician

An envelope with the participants study ID and randomization sequence was placed in storage to be opened in case of an emergency in the trial