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This interaction is mediated by dual binding, with FHD mainly binding to the p53 TAD and FOXO4 CR3 binding to the p53 DNA-binding domain (DBD) 38 (Figure

Other Gynecologic Malignancies Cervical cancer, vaginal cancer, and ovarian cancer can also cause postmenopausal bleeding, though less commonly than endometrial cancer

196 Its expression is upregulated by LPS and TNF, and the mechanism involves direct regulation by the transcription factor NF-B