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The presence of compounds like melittin, phospholipase A2, and biogenic amines in BV has been a subject of interest, with melittin, in particular, being a major toxin known for its cytotoxic effects (Shi et al., 2022)

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and those tissues when have higher levels of histamine

Moreover, agrin-treated pericytes exhibited elevated levels of ROS and Fe 2+ , along with reduced expression of GPX4 and FTH1, thereby promoting ferroptosis, suppressing pericyte proliferation, and compromising blood-brain barrier function