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Studies have suggested that exposure to the peptide even nine hours after the induction of a stroke model may help mitigate brain cell damage and cell death, as well as support parameters of learning and memory in research models

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[9] Cimetidine has been shown in controlled studies to reduce lidocaine clearance by approximately one-third after only 24 hours of co-administration, leading to higher steady-state concentrations

Anecdotally, benzyl alcohol also has a mild local anesthetic effect