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Angiogenesis and Blood Flow BPC-157 upregulates vascular pathways, particularly VEGF-related signaling and nitric oxide pathways (Akt-eNOS axis), promoting angiogenesis and improved perfusion. 2

[3] Prolonged therapy can unmask or exacerbate benign prostatic hyperplasia, raise prostate-specific antigen, worsen untreated obstructive sleep apnoea and is associated in some observational studies with a small but controversial increase in cardiovascular events, underlining the necessity for baseline and periodic monitoring of PSA, lipids and cardiovascular risk factors