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Bowatte G, Lodge CJ, Lowe AJ, Erbas B, Dennekamp M, Marks GB, et al

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Retatrutide remains investigational, available only through research channels or clinical trials

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Both Smad-dependent and non-dependent pathways greatly promote osteoblast differentiation and bone formation (Chen et al., 2012) and can regulate mesenchymal differentiation by mediating the Runx2 gene (Lee et al., 2002)

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