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This process is known as metabolic adaptation or adaptive thermogenesis

Unlike most proteins and hormones that are encoded in the cell nucleus, MOTS-c is synthesized in the mitochondria, giving it a unique and central role in metabolic regulation

More recently, researchers have discovered another receptor, called MRGPRX2, that reacts to protein fragments, such as in a viral infection, as well as drugs such as fluoroquinolone, opioids, and more