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A workforce of 10,000 with 12 percent GLP-1 uptake at even a discounted net price of $500 a month per patient generates roughly $7.2 million in annual drug spend from a single category

For the majority of the analyses, only the placebo and semaglutide 2.4 mg arms from the STEP 2 trial were analyzed ( n = 395)

Bax protein is a proapoptotic member that acts by forming pores on the mitochondrial outer membrane, allowing cytochrome c to translocate into the cytoplasm, resulting in the loss of energy production and the activation of proteolytic cascade leading to apoptosis (Westphal et al., 2014)