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Although a clear mechanistic perspective is lacking, it can be conceptualized that gut microbial dysbiosis (and its metabolites) modulates innate and adaptive immune players by recruiting immune secreting cells from the appendix, thereby priming the immune system for an enhanced inflammatory response and a possible source of -synuclein misfolding (Masahata et al., 2014
Pregnancy: Unsafe during pregnancy
Other prescription weight loss medications on the market that act on the central nervous system to suppress appetite (though by a different mechanism than GLP-1 drugs) include bupropion-naltrexone (Contrave) and phentermine-topiramate (Qsymia)
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