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Elderly patients tend to have a greater frequency of decreased hepatic, renal, or cardiac function, and also have concomitant disease or receiving other drug therapy

The most frequent dosing error is confusing reconstitution concentration with total vial content: a 5mg vial reconstituted with 2ml bacteriostatic water yields 2.5mg/ml, meaning a 200mcg dose requires 0.08ml, not 0.2ml drawing 0.2ml delivers 500mcg, a 2.5 overdose

Mild fluid retention some patients experience mild water retention, particularly in the first 2 to 4 weeks