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To gain deeper insights into the impact of the conjugate on both the brainstem and the mesolimbic reward system, we conducted complementary transcriptomics analyses (Extended Data Fig

High grade serous OC (HGSOC) is the most common and fatal epithelial OC, and most patients with HGSOC eventually develop resistance to platinum chemotherapy [73, 74]

Across multiple STEP trials, the enrollment criteria required a BMI of 30 or higher, or 27 or higher with at least one weight-related comorbidity (excluding type 2 diabetes, which was studied separately)