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GCL is composed of a catalytic (GCLC, Mr ~73 kDa) and a modifier (GCLM, Mr ~31 kDa) subunit [32] (summarized in Fig
ROS also interact with unsaturated fatty acids in phospholipids, and aldehydes such as 4-hydroxynonenal, 4-hydroxyhexanal, acrolein, and MDA are the most reactive compounds (87)
In a genome-wide association study (GWAS) involving more than 140,000 individuals of European descent, uric acid receptors encoded by twenty-eight chromosomal genes were discovered to impact plasma uric acid levels
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