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Med Clin North Am 79(1):937 Kjems LL, Holst JJ, Vlund A, Madsbad S (2003) The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjects
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Pharmacokinetics and pharmacodynamics of pegylated insulin-like growth factor-I
45,46 As shown in Figure 2 , GLP-1RAs penetrate the blood-brain barrier and directly activate GLP-1 receptors in the hypothalamus, especially within the ARH nucleus, a key center for appetite regulation
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