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Thorough analysis of their usefulness in disease improvement, safety, and metabolomics signatures, as well as the risk for addiction, resistance, and side effects, is needed [48,49]
Exenatide showed a beneficial effect on cardiovascular outcomes, albeit with borderline significance (Holman et al., 2017), whereas a separate trial of lixisenatide found no evidence of benefit (Pfeffer et al., 2015)
These findings illustrate that optimal intensification strategies are context-dependent and should consider both the magnitude and probability of clinically meaningful benefit
However, it is important to note that the enrichment of predicted targets among enzymes known to interact with viruses is still significant when removing enzymes of the respiratory chain and TCA cycle (Fishers exact test p = 9.3 10 4 , odds ratio 1.32.6)
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