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214,215 A systematic review of 12 clinical trials found that CoQ10 supplementation in patients with CKD significantly reduced blood levels of malonaldehyde, a marker of oxidative stress, and high-sensitivity C-reactive protein (hs-CRP), which is a marker of systemic inflammation
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Despite these challenges, growing evidence suggests that microbiome-associated metabolic pathways, including bile acid metabolism, short-chain fatty acid production, and tryptophan metabolism, may represent promising targets for therapeutic intervention (118)
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