Hypophosphatasie (HPP) Startseite Once affected puppies are transferred

Once affected puppies are transferred to a solid diet with digestive enzyme supplementation

DNA testing can be done at any age

life-threatening disorder of weak and thin heart

degenerative disorders characterized by progressive muscular dysfunction

Hypophosphatasie (HPP) Startseite Once affected puppies are transferredHypophosphatasia (HPP) is a rare canine autosomal recessive disease affecting bone and cartilage tissues. The symptoms include skeletal hypomineralisation, growth retardation, short stature, hypotonia, fractures, seizures and movement difficulties, meanwhile the cognition remains unharmed. Affected individuals can be stillborn or they develop mild to aggressive symptoms in the adulthood. Inheritance: autosomal recessive Mutation: ALPL gene Genetic