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It is characterized by abnormal hematologic findings
ein rezessives Allel kann an die Nachkommen weitergegeben werden
tan or pink subretinal fluid in the eye
The affected puppies often have to be euthanised due to severe symptoms and the risk of a sudden death
Zentronukleäre Myopathie (IMGD) - Deutsche Dogge Mischling It is characterized by abnormalCharacteristic signs of centronuclear myopathies include generalized muscle weakness, atrophy, predominance of type I fibres, and aberrant cell positioning of nuclei and mitochondria. In Great Danes generalized muscle atrophy, exercise intolerance, exercise induced tremor and muscle wasting characterize the disease. The disease typically starts before 10 months of age, is highly progressive, and most of the affected dogs are euthanized before 18
