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Mutation: MTM1 gene
predominance of type I fibres
Golden Retriever Muscular Dystrophy (GRMD) is a degenerative muscular disease caused by defect in protein dystrophin
which can manifest as mental and motor deterioration
Progressive Retinaatrophie, Rod-cone Dysplasie 4 (PRA-rcd4) ISAG Mutation: MTM1 geneProgressive retinal atrophy (PRA) is an inherited disease that occurs in many breeds of dogs and is reflected in various clinically indistinguishable forms. Progressive rod and cone degeneration in retina leads to progressive vision loss, which ends with total blindness. RCD4 is a form of PRA that was first described in Gordon Setters and later found in several other dog breeds. Gradual photoreceptor cell degeneration is typical for this form of the
