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It is controlled by heterozygous mutations of merle locus and a modifier harlequin locus
but it affects it in a way
As a result of severe symptoms affected dogs have a shorter life span
which is crucial for organogenesis
Immerslund-Gräsbeck Syndrom (IGS) - Riesenschnauzer Einzelanalyse It is controlled by heterozygousImerslund Grsbeck syndrome is a vitamin B12 (also known as cobalamin) deficiency characterized by its malabsorption accompanied by selective proteinuria. Vitamin B12 is water soluble vitamin, important for cell metabolism in higher organisms. Affected dogs exhibit signs of cobalamin deficiency including failure to thrive, abnormal formation of blood cells, and methyl malonic aciduria within 812 weeks of birth. Affected dogs can also exhibit
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