Polyneuropathie 1 (LPN1) - Leonberger Searchterm It is characterized by abnormal

It is characterized by abnormal hematologic findings

The symptoms become evident at 2 months of age

Acral mutilation syndrome (AMS) is a neurological disease characterized by insensitivity to pain in peripheral parts of the body (limbs

No obvious ocular or auditory involvement and secondary joint problems were detected in affected dogs like in some other diseases with short-legged phenotype

Polyneuropathie 1 (LPN1) - Leonberger Searchterm It is characterized by abnormalLeonberger Polyneuropathy 1 (LPN1) is a polyneuropathy condition (PN) that is associated with a mutation in ARHGEF10 gene. A loss of function of the gene may lead to the loss of proper nerve signalling. Polyneuropathy can display a wide range of age of onset and may appear due to the mutations in other genes (GJA9, NDRG1) with a different mode of inheritance. Clinical signs include generalized weakness, hypotonia, muscle atrophy secondary to