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MAC ist eine Immunodefizienzstörung
expressed on haematopoietic cells
Die ersten Symptome treten im Alter von etwa 4 Monaten auf und schreiten über die nächsten Jahre langsam fort
Es ist die häufigste erbliche Gerinnungsfaktor-Erkrankung
Mannosidose DNA-Profil MAC ist eine ImmunodefizienzstörungMannosidosis is a lysosomal storage disease which is characterised by accumulation of mannose rich compounds, due to the lack of the enzyme alpha mannosidase, whose task is to cleave mannose from such compounds. The symptoms usually occur at around 2 months of age and include ataxia, head tremor, dementia, aggression, hallucinatory behaviour and later in life paralysis and death. Affected dogs have to be euthanised due to severe progressive
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