Kongenitale Ichthyose - Deutsche Dogge Searchterm I-Locus causes so called »extreme

I-Locus causes so called »extreme dilution« of the pheomelanin

No obvious ocular or auditory involvement and secondary joint problems were detected in affected dogs like in some other diseases with short-legged phenotype

Mutation: C3 gene

bs or be are detected

Kongenitale Ichthyose - Deutsche Dogge Searchterm I-Locus causes so called »extremeHereditary ichthyoses represent a heterogeneous group of skin cornification disorders characterized by hyperkeratosis and blistering or scaling of different severity levels. In Great Dane the disease is characterized by severe hyperkeratosis with a formation of strongly wrinkled, thickening and scaling skin, especially in the region of eyes and nose. The symptoms become evident right after birth and thus include dry and scaling skin, untidy appearance